In 2000, Mulrow et al reported on two double-blind, placebo-controlled trials in participants with atherosclerotic lower extremity disease (Mulrow et al 2000b). One study of 64 participants showed that pain-free walking increased by approximately 40 metres with standardised dehydrated garlic (Kwai 800 mg daily) compared with approximately 30 metres with placebo over 12 weeks. Cochrane reviewers report that the effect was not significant (Jepson et al 2000). The other study of 100 participants (Mulrow et al 2000b) showed that a combination treatment of garlic oil macer© 2007 Elsevier Australia
ate/soya lecithin/hawthorn oil/wheat germ oil significantly increased the maximum walking distance (114%) compared to placebo (17%) (P< 0.05).
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