Overall, acute toxicity is unlikely with combination vitamin supplements unless huge amounts have been ingested. In the case of toxicity or side-effects, signs and symptoms will relate to the individual nutrient ingested. In general, gastrointestinal symptoms such as discomfort, nausea and diarrhoea are the most frequent adverse effects.

Of all the nutrients listed, extra special care must be taken when supplementing with vitamins A and D and the mineral iron. The forms of selenium and niacin used in practice also have a major influence on their safety profile and should be taken into consideration.

For more details regarding RDI for specific age groups:

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