Gamma-linolenic acid may be beneficial in the prevention of migraine headache when used in combination with other nutritional supplements and as part of an overall management plan, according to an open, prospective, uncontrolled trial involving 168 migraine patients. In the study, patients took a combination of GLA and alpha-LA (1800 mg/day), other vitamins, coenzymes and antioxidants, and were instructed to lower their arachidonic acid intake. They were also instructed on correct techniques of self-medication and in stress-reduction and progressive relaxation techniques. Of the 129 patients who were evaluated after 6 months, 86% reported an improvement, with 22% of the total being free from migraine, while 14% were not able to implement the self-management of progressive relaxation and stress reduction techniques. Severity and frequency of attacks were decreased in patients reporting a positive response. Significant reduction in nausea and vomiting was reported in all groups except the failure group (Wagner & Nootbaar-Wagner 1997). Evening primrose oil 400
Although encouraging, further research using GLA as a stand-alone treatment is required to determine its role in achieving these impressive results.
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