Lipidlowering

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The role of carnitine in fatty acid metabolism suggests a potential role in hyperlipidaemia. Several studies have indicated that oral l-carnitine significantly reduces lipoprotein-a levels; however, effects on other lipids are inconsistent, l-Carnitine (2 g/day) significantly reduced serum lipoprotein-a levels in 77.8% of subjects receiving active treatment after 12 weeks, according to one placebo-controlled, double-blind randomised study. No significant change was observed in other lipid parameters (Sirtori et al 2000). l-Carnitine (2 g/day) was also shown to significantly lower lipoprotein-a levels at 3 and 6 months in a double-blind placebo-controlled trial of 94 hypercholesterolemic patients with newly diagnosed type 2 diabetes (Derosa et al 2003). In a trial of children with hyperlipidaemia, lipoprotein-a levels were only reduced in those with type II homozygotes and other lipid parameters worsened (Gunes et al 2005). l-Carnitine has also been shown to decrease apolipoprotein B levels in paediatric peritoneal dialysis patients (Kosan et al 2003). A study of elderly people taking l-carnitine (2 g twice daily) demonstrated improvements in total serum cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apoproteins A1 and B at 30 days (Pistone et al 2003). Animal studies have also suggested the potential for carnitine to lower triglyceride levels (Eskandari et al 2004); however, clinical trials using oral doses in type 2 diabetes have indicated an increase in triglycerides (Rahbar et al 2005). Further human trials are required to confirm which population groups may benefit from carnitine supplementation.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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