According to in vivo research, andrographis stimulates both antigen-specific and nonspecific immune responses (Puri et al 1993). One of the main constituents responsible for the immunostimulant activity is andrographolide, which has an effect on the stimulation and proliferation of immunocompetent cells and the production of key cytokines and immune markers in vitro (Panossian et al 2002). Although important, other pharmacologically active constituents are also present as demonstrated by a study that found the immunostimulant activity of the whole extract is greater than that of the isolated andrographolide constituent alone. Investigation with a combination of the whole extract and Eleutherococcus senticosus in the formula Kan Jang demonstrated a more profound effect.
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