Immunomodula Tion

L-glutamine has demonstrated immunomodulatory activity in animal models of infection and trauma, as well as trauma in humans. L-glutamine acts as the preferred respiratory fuel for lymphocytes, is essential for cell proliferation, and can enhance the function of stimulated immune cells.

Extracellular glutamine concentration affects lymphocyte, IL-2 and IFN-gamma proliferation, cytokine production, phagocytic and secretory macrophage activities and neutrophil bacterial killing (Miller 1999, Newsholme 2001, PDRHealth 2006a). In humans, L-GIn may enhance both phagocytosis and reactive oxygen intermediate production by neutrophils (Furukawa et al 2000) and support the restoration of type-1 T-lymphocyte responsiveness following trauma (Boelens et al 2004). In a randomised trial there was a reduced frequency of pneumonia, sepsis and bacteraemia in

patients with multiple trauma who received glutamine-supplemented enteral nutrition (Houdijk et al 1998).

In addition, effects on the gastrointestinal tract may contribute significantly to immune defence by maintaining gut-associated lymphoid tissue and secretory IgA (preventing the attachment of bacteria to the gut mucosa) and maintaining gut integrity (thus preventing the translocation of microbes and their toxins, especially Gram-negative bacteria from the large intestine) (Miller 1999, Yu et al 1996).

Was this article helpful?

0 0
From Pain To Freedom

From Pain To Freedom

From Pain To Freedom is the Latest Scientific and Natural Medicine Breakthroughs to Understand and Relieve the Symptoms of Fibromyalgia!

Get My Free Ebook

Post a comment