Treatment with baicalein lowered blood pressure in hypertensive but not in normotensive rats according to one study (Takizawa et al 1998). Baical extract and baicalein have also been shown to lower blood pressure in rats and cats (Kaye et al Baical skullcap 61
1997, Takizawa et al 1998). The exact mechanisms underlying the hypotensive action
are unclear. One In vivo study has shown that Scutellaria baicalensis extract produces peripheral vasodilatation (Lin et al 1980). A recent review concluded that baical skullcap is effective for renin-dependent hypertension and that in vivo effects may be due to the inhibition of lipoxygenase, reducing the production and release of arachidonic-acid derived vasoconstrictor substances (Huang et al 2005).
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