Gastrointestinal Activity

Ginger exerts several effects in the gastrointestinal tract. It stimulates the flow of saliva, bile and gastric secretions (Platel & Srinivasan 1996, 2001, Yamahara et al 1985) and has been shown to increase gastrointestinal motility without affecting gastric emptying in several animal models and human studies (Gupta & Sharma 2001, Micklefield et al 1999, Phillips et al 1993). Ginger has also been observed to have prokinetic activity in mice in vivo and antispasmodic activity in vitro (Ghayur & Gilani 2005) These findings appear to support the traditional use of ginger in the treatment of gastrointestinal discomfort, colic, diarrhoea and bloating and its use as a carminative agent.

Anti-ulcer activity A number of in vivo studies have identified antiulcer activity for ginger extract and several of its isolated constituents. The orally administered acetone extract of ginger at a dose of 1000 mg/kg and zingiberene, the main terpenoid in this extract, at 100 mg/kg significantly inhibited gastric lesions by 97.5% and 53.6%, respectively. Additionally, the pungent principle, 6-gingerol at 100 mg/kg, significantly inhibited gastric lesions by 54.5%. These results suggest that both zingiberene and 6-gingerol are important constituents responsible for ginger's anti-ulcer activity (Yamahara et al 1988). Other constituents demonstrating antiulcer properties in gastric ulcer models in rats include beta-sesquiphellandrene, beta-bisabolene, ar-curcumene and shogaol (Sertie et al 1992, Yoshikawa et al 1994).

In addition to direct anti-ulcer activity, ginger exerts synergistic effects with the antibiotic clarithromycin in inhibiting different Helicobacter pylori isolates independent of the organisms' susceptibility to clarithromycin (Nostra et al 2006).

Was this article helpful?

0 0
Baby Sleeping

Baby Sleeping

Everything You Need To Know About Baby Sleeping. Your baby is going to be sleeping a lot. During the first few months, your baby will sleep for most of theday. You may not get any real interaction, or reactions other than sleep and crying.

Get My Free Ebook

Post a comment