Vitex is used in practice with other herbal medicines to enhance fertility in women with progesterone deficiency or luteal phase defects. Currently no large studies have been published to evaluate the effectiveness of this approach; however, a doubleblind, randomised, placebo-controlled study of 96 women with fertility disorders (38 with secondary amenorrhea, 31 with luteal insufficiency and 27 with idiopathic infertility) used the vitex product Mastodynon with encouraging results (Gerhard et al 1988). Treatment of 30 drops was administered twice daily for 3 months and resulted in women with amenorrhea or luteal insufficiency achieving pregnancy more than twice as often as the placebo group, with 1 5 women conceiving during the study period (n = 7 with amenorrhoea, n = 4 with idiopathic infertility, n = 4 with luteal insufficiency). Although promising, this study has been criticised for pooling of diverse conditions, unclear reporting of results and variable significance (Ulbricht & Basch 2005).
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