• Dermal LD50 dose: >5 g/kg (rabbit) (Citrus and Allied Essences 2004).
• Oral doses in teas and other preparations: 4-6 g/day or 2 g in 150 mL of boiled water as an infusion (American Botanical Council 1999). The inhalation LD50 dose has not been established.
• Topical application dose of bitter orange to skin exposed to UV rays: 1.4% of a blend.
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