Erythropoietic Protoporphyria And Photosensitivity

Studies in bacteria, animals and humans have demonstrated that carotenoid pigments can prevent or lessen photosensitivity by endogenous photosensitisers, such as chlorophyll or porphyrins, as well as by exogenous photosensitisers (Mathews-Roth 1993) and high doses of beta-carotene (between 180 and 300 mg/day) have been used to effectively prevent or lessen photosensitivity in most patients with erythropoietic protoporphyria and in some patients with other photosensitivity diseases such as solar urticaria, hydroa aestivale, porphyria cutanea tarda, actinic reticuloid (Mathews-Roth 1986, 1987, 1990, Mathews-Roth et al 1977).

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