DHA and EPA supplementation significantly reduces triglyceride levels and is used as sole therapy in cases of elevation or as adjunctive therapy with cholesterol-lowering medication when indicated. According to Din et al, omega-3 fatty acids reduce triglyceride concentrations in a dose-dependent manner, with intakes of about 4 g/day lowering serum triglycerides by 25-30% (Din et al 2004).
Overall, it appears that the smallest amount of omega-3 PUFA needed to lower serum triglyceride levels significantly is approximately 1 g/day, as provided by a fish diet, or as little as0.21 gEPAand0.12g DHA/day for those with hyperlipidaemia (Weber & Raederstorff 2000).
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