A controlled double-masked study of petrolatum ointment containing 10% w/w calcium carbonate applied on the lower lid twice daily for 3 months resulted in significant improvements in all criteria assessed. However, significance over placebo was only found in ocular surface staining, therefore determination of the action of

petrolatum needs to be established and controlled for In future studies to Identify the therapeutic value of calcium (Tsubota et al 1999).

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