Parthenolide-free feverfew extract is being investigated in various dermatological conditions. One study found that the formulation protected skin against inflammation and UV-induced damage (Finkey et al 2005). When the pathenolide-free feverfew extract was topically applied, it significantly reduced the loss of cell viability, the increase in proinflammatory mediator release and the induction of DNA damage induced by solar simulated UV radiation in a human epidermal model. It also exhibited potent antioxidant activity in vitro. Other in vitro tests have revealed that parthenolide-free feverfew extract reduces inflammation through several mechanisms and is being investigated further as a novel non-steroidal extract for irritated skin (Martin etal 2005).

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