Cytochrome P450 Induction

Colupulone, a beta-bitter acid, was reported to induce the cytochrome P450 system and increase mRNA levels of cytochrome 2B and 3A in rats (Shipp et al 1994). Another study found that the flavonoids from hops inhibit the cytochrome P450 system in humans, in particular cytochromes 1A1, 1 b1, 1A2, but not 2E1 or 3A4 (Henderson et al 2000). A recent review concluded that hops inhibits phase 1 detoxification and enhances phase two by inducing quinone reductase (Gerhauser et al 2002, Stevens & Page 2004). The clinical significance of these findings is unknown.

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