Supplemental forms used in trials include organic chromium complexes, such as chromium picolinate and chromium nicotinate, and inorganic salts such as chromium chloride. Considering chromium is known to improve insulin sensitivity, a theoretical basis exists for its use in conditions associated with insulin resistance such as type 2 diabetes mellitus, gestational diabetes, hypoglycaemia, polycystic ovarian syndrome, obesity, and syndrome X. For many of these indications, controlled studies are not yet available. However, there has been investigation into its use in diabetes, hypoglycaemia, hyperlipidaemia and obesity. DEFICIENCY STATES — PREVENTION AND TREATMENT
Although chromium deficiency is uncommon (Vincent 2004) and mostly described in relation to the use of TPN without chromium, subclinical deficiency states also exist and should respond to supplementation (Verhage 1996). Chromium supplementation is also used in cases at risk of deficiency, such as long-term corticosteroid use (Kim et al 2002) or people with a high sugar intake (Kozlovsky et al 1986).
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