Chromium exists mostly in two valence states in nature: hexavalent chromium (chromium (VI)) and trivalent chromium (chromium (III)). The hexavalent form is used in industry and is associated with toxicity. Trivalent chromium is an essential trace element in the human body and approved as a supplement.
Supplemental forms used in trials include organic chromium complexes such as chromium picolinate and chromium nicotinate and inorganic salts such as chromium chloride. Nicotinic acid is also a metabolite of tryptophan improving its absorption; however, the picolinate form is the one surrounded by the most controversy.
Was this article helpful?