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Although clinical trials are not available, the results from several in vivo studies have suggested a potential role for andrographis in cardiovascular disease. Prevention of atherosclerotic arterial stenosis and restenosis after angioplasty According to two animal studies, andrographis significantly improved atherosclerotic iliac artery stenosis induced by both de-endothelialisation and a high-cholesterol diet, and reduced the restenosis rate after experimental angioplasty (Wang & Zhao 1993, 1994).

Prevention of myocardial reperfusion injury and malignant arrhthymias postoperatively Using an animal model, pretreatment with intravenous

andrographis significantly protected the myocardium from ischaemic reperfusion injury and eliminated malignant arrhythmia development after reperfusion, compared with controls (Guo et al 1996). As a result of treatment, infarct size was also smaller and myocardial damage lessened.

Hypertension Andrographis produced significant dose-dependent falls in mean arterial blood pressure and heart rate when administered as an intraperitoneal infusion in one animal study (Zhang et al 1998).

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