Currently, controlled studies are not available to determine the clinical effectiveness of CoQ10 in cancer; however, there have been several case reports of CoQ10 (390 mg/day) successfully reducing metastases or eliminating tumours entirely (Lockwood et al 1994, 1995). An in vivo study found that CoQ10 enhances the effects of immunochemotherapy (Kokawa et al 1983).
There is some evidence that CoQ10 supplementation protects the mitochondria of the heart from anthracycline-induced damage. A systematic review of six studies (three randomised) in which patients in five of the six studies received anthracyclines concluded that CoQ10 provides some protection against cardiotoxicity or liver toxicity during cancer treatment; however, the results were not conclusive and further research is required (Roffe et al 2004).
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