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Synephrine produces effects on human metabolism, which could be useful for reducing fat mass in obese humans because it stimulates lipolysis, raises metabolic rate and fat oxidation through increased thermogenesis (Pellati et al 2002). A controlled in vivo study of C. aurantium fruit hydro-alcoholic extracts standardised to synephrine 4% ( 4%) and 6% ( 6%) found repeated administration of the extract significantly and dose-dependently reduced food intake and body weight gain (Calapai et al 1999).

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