It has been suggested that gingerols and their derivatives represent a potential new class of platelet activation inhibitors, with synthetic gingerols being found to inhibit the arachidonic acid-induced platelet release reaction in vitro in a similar dose range as aspirin possibly due to an effect on COX activity in platelets (Koo et al 2001, Lu 2005, Nurtjahja-Tjendraputra etal 2003, Tjendraputra etal 2001).
Powdered ginger exerted an antiplatelet activity when taken in very high doses of at least 10 g, according to one human study (Bordia et al 1997). A randomised double-blind study found that doses up to 2 g of dried ginger had no effect on bleeding time, platelet aggregation or platelet count (Lumb 1994). This lack of effect has been demonstrated in healthy volunteers (Janssen et al 1996) and those with type 1 diabetes mellitus or coronary artery disease (Bordia et al 1997).
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