Grapeseed PC extract has demonstrated excellent free radical scavenging abilities, in both test tube and animal models, and provided significantly greater effects than vitamins C, E and beta-carotene (Bagchi et al 1997, 1998, 2000a, 2001, Castillo et al 2000, Facino et al 1999, Fauconneau et al 1997, Maffei et al 1994, 1996). In vitro tests have further identified a vitamin E sparing effect, in which PCs prevent vitamin E loss and cause alpha-tocopherol radicals to revert to their antioxidant form (Maffei et al 1998).

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