A number of in vitro and in vivo studies confirm the anti-inflammatory activity of Aloe vera.
The gel reduces oxidation of arachidonic acid, thereby reducing PG synthesis and inflammation (Davis et al 1987). It inhibits the production of PGE2 by 30% and IL-8 by 20%, but has no effect on thromboxane B2 production in vitro (Langmead et al 2004). Following burn injury in vivo, A. vera was also found to inhibit inflammation by reducing leukocyte adhesion and decreasing the pro-inflammatory cytokines TNF-alpha and IL-6 (Duansak et al 2003).
One study conducted on rats with croton oil-induced oedema reported a 47% reduction in swelling after the application of topical aloe gel (Davis et al 1989). Another study found aloe gel to reduce vascularity and swelling by 50% in the inflamed synovial pouch in rats, along with a 48% reduction in the number of mast cells in the synovial fluid within the pouch. When aloe gel was applied topically there was also an increase in fibroblast cell numbers (Davis et al 1992). C-glucosyl © 2007 Elsevier Australia
chromone, isolated from aloe gel extracts, Is chiefly responsible for the anti-Inflammatory effect, with activity comparable to hydrocortisone In experimental models (Hutter et al 1996). A study of streptozotocln-lnduced diabetic mice further confirmed the anti-Inflammatory activity of A. vera and Identified the Isolated constituent glbberellln as also effective (Davis and Maro 1989). Both compounds Inhibited Inflammation In a dose dependant manner.
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