Based on the observation of relative CoQ10 deficiency in patients with ischaemic heart disease, and in animal models showing that it prevents reperfusion injury, © 2007 Elsevier Australia
several randomised clinical trials have been performed in angina pectoris. The doses used have varied from 60 mg to 600 mg daily, and the time frames for use varied from 4 days to 4 weeks. Overall, CoQ10 appears to delay signs of oxygen deficiency in the myocardium, increases patients' stamina on a treadmill or during exercise and delays the onset of angina (Overvad et al 1999), as well as reducing nitroglycerin consumption (Kamikawa et al 1985).
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