It has been estimated that approximately 1 In 30,000 people using SJW will experience an adverse reaction, including those attributed to drug interactions (Schulz 2006). The incidence of side-effects to SJW is approximately 10-fold lower than for conventional antidepressants (SSRIs). According to an overview of 16 postmarketing surveillance studies, gastrointestinal symptoms, sensitivity to light and other skin conditions and agitation were the most commonly reported side-effects and were generally described as mild (Linde & Knuppel 2005). PHOTOSENSITIVITY (UNLIKELYAT THERAPEUTIC DOSES) The most common adverse event among spontaneous reports is photosensitivity, which is estimated to occur in 1 in 300,000 treated cases. This can occur with a dose of 5-10 mg/day hypericin, which is 2-4-fold higher than the recommended dose. Commission E has noted the possibility of photosensitivity reactions, particularly in fair-skinned people.
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