Furanocoumarins, such as bergapten and psoralen, which are in dong quai have been widely studied for their phototoxicity; however, only Angelica gigas (Korean angelica) Dong quai 364
has been demonstrated to cause photodermatitis.
Safrole, found in the volatile oil, is a potential carcinogen; however, no specific cases of carcinogenesis have been reported (Micromedex 2003).
High doses of dong quai volatile oil have been reported to cause nephrosis in rats but there are no reports in humans (Zhu 1987).
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