Vitamin B12 deficiency pernicious anaemia

Although well recognised, this is a much less common cause of macrocytosis than the foregoing conditions. It is usually caused by lack of intrinsic factor due to autoimmune atrophic changes and by gastrectomy. Anaemia does not develop for about three years after total gastrectomy. B12 deficiency may also be seen together with other deficiencies in some cases of malabsorption and Crohn's disease.

Vitamin B12 is found only in foods of animal origin and consequently very strict vegetarians may eventually develop deficiency. The clinical features are anaemia (macrocytic), weight loss and neurological symptoms especially a polyneuropathy. The serum Vitamin B12 is below the normal level.

Dealing With Back Pain

Dealing With Back Pain

Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.

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