Symptoms

• general constitutional, e.g. malaise

• symptoms of anaemia

• susceptibility to infection, e.g. sore throat, mouth ulceration, chest infection

• easy bruising and bleeding, e.g. epistaxis, gingival bleeding

• bone pain (notably in children with ALL) and joint pain

• symptoms due to infiltration of tissues with blast cells, e.g. gingival hypertrophy in AML

miserable, irritable (80%)

testicular enlargement '

miserable, irritable (80%)

__raised intracranial pressure (2%)

increasing paleness

- pain on walk ng or being held

Fig. 23.1 Clinical features of a child with leukaemia 4

__raised intracranial pressure (2%)

increasing paleness

- pain on walk ng or being held

Fig. 23.1 Clinical features of a child with leukaemia 4

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