Moclobemide 150 mg (o) bd. If no response after 2 to 3 weeks, increase by 50 mg daily to maximum 300 mg (o) bd.

• This is a reversible MAOI, which is less toxic than the irreversible MAOIs.

• It has minimal interaction with tyramine-containing foodstuffs, so that no dietary restrictions are necessary.

• Adverse effects include nausea, headache, agitation, dizziness and insomnia.

• The irreversible MAOIs, which should be reserved for second-line MAOI therapy, include phenelzine and tranylcypromine.

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