Drug prophylaxis

Allopurinol (a xanthine oxidase inhibitor) is the drug of choice.

Dose: 100-300 mg daily


• frequent acute attacks

• tophi or chronic gouty arthritis

• renal stones or uric acid nephropathy

• hyperuricaemia

Beware of renal insufficiency and elderly patients—use lower doses. Method

• Commence 4 weeks after last acute attack.

• Start with 100 mg daily and increase by 100 mg daily after each month.

• Check uric acid level after 4 weeks: aim for level < 0.38 mmol/L

• Add colchicine 0.5 mg bd for 6 months (to avoid precipitation of gout) or indomethacin 50 mg bd.

The spondyloarthropathies

The spondyloarthropathies are a group of disorders with common characteristics affecting the spondyles (vertebrae) of the spine. It is appropriate to regard them as synonymous with the seronegative spondyloarthropathies in contradistinction to rheumatoid arthritis, which is seropositive and affects the cervical spine only. Apart from back pain this group tends to present with oligoarthropathy in younger patients.

Was this article helpful?

0 0
Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

Get My Free Ebook

Post a comment