Diagnostic tests

• normocytic normochromic anaemia may be present

• antinuclear antibodies—up to 90% positive (relatively specific)

• rheumatoid factor—positive in 30%

• anticentromere Abs—specific (positive in 90% with limited disease and 5% with diffuse)

• antitopoisomerase I (anti-Scl-70) antibody is specific but only positive in 20-40%

• skin biopsy—increase in dermal collagen

Body Language

Body Language

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