Cytomegalovirus infection

Cytomegalovirus (CMV) has a worldwide distribution and causes infections that are generally asymptomatic. The virus (human herpes virus 5) may be cultured from various sites of healthy individuals. It has its most severe effects in the immunocompromised, especially those with AIDS, and also in recipients of solid organ transplants and bone marrow grafts; 90% of AIDS patients are infected with CMV and 95% have disseminated CMV at autopsy. CMV infection can be an important development following massive blood transfusion, including those given to infants. The incubation period of CMV ranges from 20 to 60 days and the illness generally lasts about 2 to 6 weeks. 4

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