Common clinical features

CD4count

Seroconversion illness

(self-limited 1-3 weeks)

Asymptomatic

Symptomatic—early

Symptomatic—late

Fever, headache (may have aseptic meningitis), sore throat, maculopapular rash, lymphadenopathy, splenomegaly; Atypical lymphocytes on FBE

Headaches

Persistent generalised lymphadenopathy

Oral and vaginal candidiasis, oral hairy leukoplakia, seborrhoeic dermatitis, psoriasis, recurrent varicella-zoster infection, cervical dysplasia, unexplained fever, sweats, weight loss, diarrhoea, tuberculosis

PCP, Kaposi's sarcoma, oesophageal candidiasis, cerebral toxoplasmosis, lymphoma, HIV-1 associated dementia complex, cryptococcal meningitis

Transient decrease, commonly followed by a return to near normal levels

Usually > 300M_ Gradual decrease of 50-80A_

Usually 150-500AL

Usually < 150M_

CMV retinitis, cerebral lymphoma, .. ..

Mycobacterium avium complex (MAC) infection

Reproduced with permission 6

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