• incubation period 3-20 days (average 10)
• severe headache
• macular rash: conjunctivitis
Some may develop the immune phase (after an asymptomatic period of 1-3 days) with aseptic meningitis or jaundice and nephritis (icterohaemorrhagic fever, Weil's disease) with a significant mortality.
• high or rising titre of antibodies: can be cultured
• doxycycline 100 mg (o) bd for 5-7 days or benzylpenicillin 900 mg IV, 6 hourly for 5-7 days
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