Clinical features

• insidious onset but can begin acutely (explosive RA)

• any age 10-75 years—peak 30-50 years but bimodal 25-50 (peak age) and 65-75

• joint pain o worse on waking, nocturnal pain, disturbed sleep o relieved with activity

• morning stiffness—can last hours

• rest stiffness, e.g. after sitting

• general: malaise, weakness, weight loss, fatigue

• disability according to involvement

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