Antidepressant medication

The initial choice of an antidepressant depends on the age and sex of the patient, prior response to medication, safety in overdosage and the sideeffect profile. All antidepressants are equally efficacious. The tricyclics and tetracyclics have been the first-line drugs but the newer drugs, the selective serotonin reuptake inhibitors and moclobemide (a reversible monoamine oxidase inhibitor (MAOI) antidepressant) are equally effective, are better tolerated, have a wider safety margin 6 and are now considered first-line drugs.

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