Considering the potential toxicity of formaldehyde or glutaralde-hyde, Sung et al8) from Taiwan suggested that the cross-linking method of GRF be changed. They used an epoxy compound (GRE glue), a water-soluble carbodimide (GAC glue), or a genipin (GG glue) to cross-link with gelatin as a new adhesive. In their comparative study, they concluded that GRE glue is not suitable for bioad-hesion in clinical applications. GRF and GRFG glue may be used when their ability to bind tissue tightly and rapidly is needed. They also concluded that GAC and GG glues can be used when minimal cytotoxicity and stiffness are required during adhesive action. In 1995, Basu et al.,77 in their comparative study between cryoprecipitate glue, French glue, and two-component fibrin sealant in controlling suture line and surface bleeding from standardised atriotomy and aortotomy, concluded that GRFG glue is a good tissue reinforcer; fibrin sealant is preferable as a haemostatic agent if accompanied with a mechanical barrier; and cryoprecipitate glue maybe used when haemostasis is the only concern.
In 2000, Chan et al.81 conducted an experiment on swine model of splenic haemorrhage to compare Poly-N-Acetyl Glucosamine (P-GlcNAc) with absorbable collagen (Actifoam), fibrin sealant (Bolheal), and surgicel. P-GlcNAc was found to be more effective and promising as a topical haemostatic agent in both unheparinised as well as anticoagulated animals.
Was this article helpful?