Cellulose with Thrombin

In 1942, Uihlein et al.19,20 suggested the use of oxidised cellulose as a haemostatic sealant. Absorbable oxidised cellulose was used as a haemostatic sealant, especially for neurosurgical preparations. Absorbable oxidised cellulose was prepared in the form of transparent gauze-like material and a heavier material that resembled absorbent cotton. The manufacturer also supplied concentrated dried thrombin ampoules. In 1943, Frantz21 reported the results of some experimental studies with oxidised cellulose, in animals. She stated that it was absorbed when implanted into animal tissues and had little cellular reaction. It was mildly irritating when placed on the surface of the brain. Galbraith22 also used it in experimental animals after soaking it in a solution of thrombin and applying to bleeding surfaces. Cronkite et al.23 found that a combination of thrombin with soluble cellulose appeared to be ofvalue for local haemostasis in both traumatic and elective surgical procedures.

Uihlein et a/.19,20 in 1945 used absorbable oxidised cellulose to try and control oozing and bleeding in 22 surgical, 20 neurosurgical, 11 otolaryngologic, four orthopaedic, and three rectal operations. Excellent, immediate haemostasis was obtained in 37 cases (62%)

and satisfactory in 20 cases (33%), in which, either the gauze-like or cotton-like material was used. In three cases (5%), the cotton-like material failed to control bleeding satisfactorily. Specially prepared absorbable oxidised cellulose, with a solution of thrombin was tried by various surgeons of the Mayo Clinic as an aid to haemostasis, in 60 cases. Haemostasis was excellent and immediate in 37 cases and satisfactory in 20 cases.

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