Conformational Studies

A detailed appreciation of the biological function of a molecule requires that its conformation be understood. Therefore, in recent years a great deal of effort has been directed toward elucidating the solution conformation of oligosaccharides [92]. The work, however, has been heavily focused on oligopyranosides. At the same time, a wealth of information detailing the conformation of furanose rings in nucleotides and nucleic acids has accumulated [93]. However, except for sucrose [94,95], only recently have conformational investigations of oligosaccharides containing furanose residues been reported [96,97]. Outlined in this section are some recent investigations that have explored the solution conformation of methyl a-d-arabinofuranoside and oligosaccharides containing a-d-arabinofuranosyl residues.

Figure 17 Synthesis of 62: IDCP, iodine dicollidine perchlorate; TBDPS, r-butyldiphen-vlsilvl.
0 0

Post a comment