Syntheses And Structural Characterization Of Amidolinked Oligomers With Stable Secondary Structure

A. Non-Carbohydrate-Based Materials

Although this chapter is focused on carbohydrate-based compounds, it is important to briefly describe the pioneering work of Gellman and Seebach directed to the syntheses of amido-linked oligomers derived from ยก- and y-amino acids that are not based on carbohydrates. These researchers and others [55] have engineered systems that adopt stable helical, sheet, and turn conformations in solution. Surprisingly, in many cases as few as four residues is sufficient to stabilize the conformation. This completely contrasts with oligomers derived from a-amino acids which typically require many more residues before conformational stability is established [56].

10-mer Bases =TCACTAGATG 13-mer bases = TCTTCCTCTCTCT Carboxy termini capped with L-lysine ho

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Good Carb Diet

Good Carb Diet

WHAT IT IS A three-phase plan that has been likened to the low-carbohydrate Atkins program because during the first two weeks, South Beach eliminates most carbs, including bread, pasta, potatoes, fruit and most dairy products. In PHASE 2, healthy carbs, including most fruits, whole grains and dairy products are gradually reintroduced, but processed carbs such as bagels, cookies, cornflakes, regular pasta and rice cakes remain on the list of foods to avoid or eat rarely.

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