Selective Uptake by the Hepatic Lectin of an Antisense Oligonucleotide Saccharide Epitope Conjugate

In analogy to the results obtained for targeting genes, it is expected that the endo-cytotic abilities of the hepatic lectin could also delivery oligonucleotides for antisense

Figure 18 Covalently linked oligonucleotides could be delivered to hepatocytes via attachment to the GlcNAc cluster ligand YEE(ah-GalNAc)3 24.

Figure 19 Construct 28 was used for luciferase gene delivery to hepatocytes by noncovalent association of the gene to GalNAc cluster 24.

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