AHB = (S)-4-amino-2-hydroxybutyryl

AHB = (S)-4-amino-2-hydroxybutyryl

Compounds 28-36

The aminoglycoside antibiotic 66-40G produced by Micromonospora inyoensis is 3"-jV-demethylsisomicin [70], and the G-367S (compound 66; see pg. 317) produced by a strain of Dactylosporangium, has been characterized as 2'-jV-formylsi-somicin [71].

Seldomycins (compounds 67-69 ; see pg. 318) are another set of structurally related gentamicin aminoglycosides in this group. Seldomycin 5 is the most potent, having a methoxy group at the 4"-position of xylopyranose ring [72]. Seldomycin 2 is a pseudodisaccharide lacking the xylopyranose moiety. Seldomycin 5 is the only naturally occurring aminoglycoside antibiotic that has an amino group at the 2"-position next to the 3"-amino group.

2. Aminoglycosides Containing Streptamine, Streptidine, and Their Derivatives

(a) Streptamine-Containing Aminoglycosides. One of the aminoglycosides bearing a streptamine ring in its structure is SS-56C (Section II.A.1.b) [38], which is struc

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