Figure 21 Whitesides's copolymerization of SA acrylamide 30 and various copolymerants 31 yielded mixed copolymers of altered carbohydrate density.
polymers inhibited the adhesion of polyclonal antivirus antibodies that do not bind HA, thus supporting the hypothesized role of steric stabilization . Additional support was provided by the observation that the addition of monovalent neuramin-idase inhibitors to a solution of virus-bound polymer increased the potency of the polymer . Neuraminidase binds sialic acid residues but does not contribute measurably to agglutination; consequently, the addition of neuraminidase inhibitors could promote the release of polymer side chains involved in nonproductive neuraminidase binding. The result would be an increase in the effective volume of the polymer, which should increase the observed activity of the polyvalent ligand through steric stabilization.
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