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Man = a-D-mannopyranosyl Compounds 73-78

Man = a-D-mannopyranosyl Compounds 73-78

B, istamycins A0 and B0) show less potency (compounds 99-111 ; see pgs. 322 and 323).

Sannamycin C (compound 112; see pg. 323) is a fortimicin analog, and its 4-N-glycyl derivative inhibits gram-positive and gram-negative bacteria resistant to other aminoglycoside antibiotics [108]. In sannamycin C the methoxy group at position 3 is equatorial, whereas in sannamycin B the methoxy group holds an axial position.

Compounds 80-84

Valienamine Valiolamine (R1 = R3 = R4 = H, R2 = OH) (R5 = R6 = H) Validamine (R1 = R2 = R3 = R4 = H)

R2 R3

R4 R5

References

R2 R3

R4 R5

References

85 Validamycin A

ß-glc

0 0

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