Compounds 61-65

weak antibacterial activity but exhibits a broad spectrum of activity against grampositive and gram-negative bacteria, including aminoglycoside-resistant strains [95].

Antibiotic X-14847 (compound 98; see pg. 321), produced by Micromonospora echinospora, has been identified at 1-0-(2-amino-2-deoxy-a-d-glucopyranosyl)-d-myo-inositol showing weak antibiotic activity [96].

(b) 1,4-Diaminocyclitol-Containing Aminoglycosides. This class includes fortim-icins and related analogs. They are active antibiotics against most gram-positive and gram-negative bacteria, including those with resistant strains, but they are not active against Pseudomonas. In this class, the glycyl moiety plays an important role in activity of the compound, and those without this component (fortimicin B, sporaricin

v-NHMe 0-^pCH3 OH

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