Overview Of Metabolic Substrate Engineering

The complex glycoconjugates expressed on eukaryotic cell surfaces (Figs. 3-8) comprise primarily 10 monosaccharides: Glc, Gal, Man, Fuc, GlcN, GlcNAc, GalNAc, Xyl, GlcUA, and sialic acid (Neu5Ac). These sugars can be biosynthesized de novo within a cell, often from Glc; or, in many cases, key metabolic intermediates can be supplied exogenously to a cell. The pathways for these interconversions are summarized in Figure 9 [33-36]. If the enzymes in these biosynthetic pathways could tolerate unnatural substrates, subtle modifications, such as replacement of a hydroxyl group with a hydrogen atom or halogen, could be introduced into cell surface gly-cans. This possibility attracted the attention of many groups interested in understanding how specific carbohydrate structures dictate molecular and cellular interactions.

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Biochemistry Common Core Oligosaccharide

Figure 3 The oligosaccharide Glc3Man9GlcNA2 is a common precursor in the biosynthesis of the three types of N-linked 4 oligosaccharides. 01

Figure 3 The oligosaccharide Glc3Man9GlcNA2 is a common precursor in the biosynthesis of the three types of N-linked 4 oligosaccharides. 01

Figure 4 Examples of the three types of N-linked oligosaccharides found in human a-galactosidase A. Their common core structure is shown in gray.

Figure 4 Examples of the three types of N-linked oligosaccharides found in human a-galactosidase A. Their common core structure is shown in gray.

The Sugar Solution

The Sugar Solution

Curb Sugar Cravings Once And For All With These Powerful Techniques. Sugar sensitive people might be low in specific neurochemicals that help us feel calm, centered, confident, and optimistic. Sugar is a drug that temporarily makes the sugar sensitive feel better, but with damaging consequences.

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