Ho

OAc P°2Me

C02Na

2. BrCH2C02fBu ( N02 DIPEA, CH2CI2, 68%

2. BrCH2C02fBu ( N02 DIPEA, CH2CI2, 68%

•NHR

2. NaOMe, MeOH then NaOH

2. NaOMe, MeOH then NaOH

Scheme 10

tors such as steric stabilization have also been invoked to support the observations [92]. It is clear, however, that a closer examination of the active site's topography is a critical factor to be elucidated for the sake of better designing potent ligands/ inhibitors. With this criterion in mind, increasing activity is being addressed in attempts to design neoglycoconjugates of intermediate size between small clusters (di-/trimers) and glycopolymers. Glycodendrimers seem to fulfill the foregoing requirement. Each neoglycoconjugate has its own strength and weaknesses and ultimately, it is the targeted application that will dictate which glycoforms will be favorable. Section V provides a brief overview of the progress and limitations encountered during the development of glycodendrimers since their first synthesis in 1993 [93].

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