To explore structure-function relationships and optimize their activities, NeuAc-substituted acrylamide polymers were prepared with a variety of appended functional groups (Fig. 22) . These studies generated polymers with very high inhibitory potencies toward HA. For example, an acrylamide copolymer substituted with 10% benzylamine and 20% NeuAc residues had a Kl of 0.6 nM . Both the chelate effect and steric stabilization were mechanisms suggested to contribute to the potent activity of this and related materials (Fig. 5). The NeuAc-substituted acrylamide
Figure 21 Whitesides's copolymerization of SA acrylamide 30 and various copolymerants 31 yielded mixed copolymers of altered carbohydrate density.
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