Pellagra Is Caused by Deficiency of Tryptophan Niacin

Pellagra is characterized by a photosensitive dermatitis. As the condition progresses, there is dementia, possibly

Nicotinic acid Nicotinamide

Nicotinic acid Nicotinamide

OH OH NAD

Figure 45-11. Niacin (nicotinic acid and nicotinamide) and nicotinamide adenine dinucleotide (NAD). * Shows the site of phosphorylation in NADP.

OH OH NAD

Figure 45-11. Niacin (nicotinic acid and nicotinamide) and nicotinamide adenine dinucleotide (NAD). * Shows the site of phosphorylation in NADP.

diarrhea, and, if untreated, death. Although the nutritional etiology of pellagra is well established and trypto-phan or niacin will prevent or cure the disease, additional factors, including deficiency of riboflavin or vitamin B6, both of which are required for synthesis of nicotinamide from tryptophan, may be important. In most outbreaks of pellagra twice as many women as men are affected, probably the result of inhibition of tryptophan metabolism by estrogen metabolites.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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