Many Coenzymes Cofactors Prosthetic Groups Are Derivatives of B Vitamins

The water-soluble B vitamins supply important components of numerous coenzymes. Many coenzymes contain, in addition, the adenine, ribose, and phosphoryl moieties of AMP or ADP (Figure 7-2). Nicotinamide and riboflavin are components of the redox coenzymes

HH HO

Arg 145

His 196

Arg 145

His 69

Tyr 248

Glu 72

His 69

Tyr 248

Figure 7-3. Two-dimensional representation of a dipeptide substrate, glycyl-tyrosine, bound within the active site of carboxypeptidase A.

Figure 7-2. Structure of NAD+ and NADP+. For NAD+, R = H. For NADP+, R = PO32-.

NAD and NADP and FMN and FAD, respectively. Pantothenic acid is a component of the acyl group carrier coenzyme A. As its pyrophosphate, thiamin participates in decarboxylation of a-keto acids and folic acid and cobamide coenzymes function in one-carbon metabolism.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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